Hydrochloric Acid → {4-[6-(4-Ethyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-benzoxazol-2-yl]-phenoxy}-acetaldehyde

HRID 1620012Notes

Reaction equation

HRID 1620012 reaction equation
C[O:2][CH:3](OC)[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[O:13][C:14]3[CH:20]=[C:19]([C:21]4[CH:22]([CH2:28][CH3:29])[CH2:23][C:24](=[O:27])[NH:25][N:26]=4)[CH:18]=[CH:17][C:15]=3[N:16]=2)=[CH:8][CH:7]=1.Cl.O1CCOCC1>CC(=O)OCC>[CH2:28]([CH:22]1[CH2:23][C:24](=[O:27])[NH:25][N:26]=[C:21]1[C:19]1[CH:18]=[CH:17][C:15]2[N:16]=[C:12]([C:9]3[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH:3]=[O:2])=[CH:7][CH:8]=3)[O:13][C:14]=2[CH:20]=1)[CH3:29]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67465409HCID 67465409, compound

Product 1

HCID 86689077{4-[6-(4-Ethyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-benzoxazol-2-yl]-phenoxy}-acetaldehyde

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

22.2 mg (52 μmol) 6-{2-[4-(2,2-dimethoxy-ethoxy)-phenyl]-benzoxazol-6-yl}-5-ethyl-4,5-dihydro-2H-pyridazin-3-one, 130 μL (4 mmol/mL; 520 μmol) HCl and 2 ml dioxane are stirred for 3 h at 50° C. Then the mixture is diluted with EA, extracted with H2O and then with 10% sodium carbonate solution. The solv. of the org. phase is eliminated i.V.

Workup

  1. extractionextracted with H2O

Sources & evidence

ORD record
ord-dfd884c16b2f48839117004cb81740ca
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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