5-methyl-6-(2-thiophen-2-yl-benzoxazol-6-yl)-4,5-dihydro-2H-pyridazin-3-one → 5-methyl-6-(2-thiophen-2-yl-benzoxazol-6-yl)-2H-pyridazin-3-one

HRID 1620017Notes

Reaction equation

[CH3:1][CH:2]1[C:7]([C:8]2[CH:21]=[CH:20][C:11]3[N:12]=[C:13]([C:15]4[S:16][CH:17]=[CH:18][CH:19]=4)[O:14][C:10]=3[CH:9]=2)=[N:6][NH:5][C:4](=[O:22])[CH2:3]1>[O-2].[Mn+4].[O-2].O1CCOCC1>[CH3:1][C:2]1[C:7]([C:8]2[CH:21]=[CH:20][C:11]3[N:12]=[C:13]([C:15]4[S:16][CH:17]=[CH:18][CH:19]=4)[O:14][C:10]=3[CH:9]=2)=[N:6][NH:5][C:4](=[O:22])[CH:3]=1

Participants

Conditions

Temperature: 120 °C

Procedure

100 mg (321 μmol) 5-methyl-6-(2-thiophen-2-yl-benzoxazol-6-yl)-4,5-dihydro-2H-pyridazin-3-one, 0.08 mg (964 μmol) activated manganese(IV)oxide and 10 ml dioxane are combined and stirred overnight at 120° C. The reaction mixture is filtered through Celite, washed with DCM and EA and the solv. of the filtrate is eliminated i.V. The residue is recrystallised with DMF.

Workup

filtrationThe reaction mixture is filtered through Celite
washwashed with DCM and EA
customThe residue is recrystallised with DMF

Sources & evidence

ORD record: ord-cc012d534f784aa091530b9e63683dbe
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08772323B2

Reaction notes

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