HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 6-Bromo-7-hydroxychroman-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 7-Hydroxychromanone | HCID 298130 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 6-Bromo-7-hydroxychroman-2-one | HCID 46835416 | 54.9% |
Reaction Steps
A solution of Intermediate 1 (20 g) in acetonitrile (50 ml) was added with N-bromosuccinimide (20 g, WAKO) under ice cooling, and stirred for 10 minutes under ice cooling, and then stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure, and then recrystallized from acetonitrile to obtain the title compound (15 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772327B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-dc0c4128f5c74da9b017499c0d4ff735 |
| Source note | uspto-grants-2014_07 |