Dichloromethane → HCID 28390123, compound

HRID 1620034Notes

Reaction equation

HRID 1620034 reaction equation
[OH2:1].[OH2:2].O[C:4]1[C:12]2N=N[NH:9][C:8]=2[CH:7]=[CH:6][CH:5]=1.ON1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2N=N1.Cl.[CH2:24](N=C=NCCCN(C)C)[CH3:25].Cl[CH2:36]Cl>>[C:24]([C:4]1[CH:12]=[C:8]([NH:9][C:36](=[O:2])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[OH:1])[CH:7]=[CH:6][CH:5]=1)#[CH:25]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 178526972HCID 178526972, compound

Product 1

HCID 28390123HCID 28390123, compound

Procedure

The compound A (0.276 g, 2 mmol) is dissolved in 10 mL of dichloromethane, 1-Hydroxybenzotriazole Hydroxybenzotriazole monohydrate monohydrate (0.270 g, 2 mmol) and N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.383 g, 2 mmol) are then added thereinto. The abovementioned solution is added by 3-Ethynylanlilne (the compound B, 0.258 ml, 2.2 mmol) and stirred under room temperature for 66 hours. The mixture is treated by using a rotary evaporator. After extracting by dichloromethane and removing water by magnesium sulphate, the precipitate is collected and washed by hot ethanol, so as to obtain the purple compound No. 3.

Workup

  1. additionThe mixture is treated
  2. customa rotary evaporator
  3. extractionAfter extracting by dichloromethane
  4. customremoving water by magnesium sulphate
  5. customthe precipitate is collected
  6. washwashed by hot ethanol
  7. customso as to obtain the purple compound No

Sources & evidence

ORD record
ord-9533372059e64d32b1853985f382d6d0
Source dataset
uspto-grants-2014_07
Patent number
US08772344B2

Reaction notes

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