HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1620069Generated: October 26, 2026
Dimethylformamide dimethyl acetal → 1-(5-Bromopyridin-3-yl)-3-(dimethylamino)prop-2-ene-1-one
https://huagongshe.com/reaction/1620069
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 3-Acetyl-5-bromopyridine | HCID 820423 | — |
| Product | 1-(5-Bromopyridin-3-yl)-3-(dimethylamino)prop-2-ene-1-one | HCID 67057279 | — |
Reaction Steps
An N,N-dimethylformamide dimethylacetal (2 ml) solution containing 1-(5-bromopyridin-3-yl)ethanone (100 mg) (WO2009/87224 A1) was stirred at 100° C. for 5 hours. The solvent was distilled away under reduced pressure, and a yellow solid of 1-(5-bromopyridin-3-yl)-3-(dimethylamino)prop-2-ene-1-one was thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08772320B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-8371d949cecf46f8ac72016070dd130c |
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| Source note | uspto-grants-2014_07 |
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