Dimethylformamide dimethyl acetal → 1-(5-Bromopyridin-3-yl)-3-(dimethylamino)prop-2-ene-1-one

HRID 1620069Notes

Reaction equation

HRID 1620069 reaction equation
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[Br:9][C:10]1[CH:11]=[C:12]([C:16](=[O:18])[CH3:17])[CH:13]=[N:14][CH:15]=1>>[Br:9][C:10]1[CH:11]=[C:12]([C:16](=[O:18])[CH:17]=[CH:3][N:4]([CH3:5])[CH3:6])[CH:13]=[N:14][CH:15]=1

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 8204233-Acetyl-5-bromopyridine

Product 1

HCID 670572791-(5-Bromopyridin-3-yl)-3-(dimethylamino)prop-2-ene-1-one

Conditions

Temperature
100 °C

Procedure

An N,N-dimethylformamide dimethylacetal (2 ml) solution containing 1-(5-bromopyridin-3-yl)ethanone (100 mg) (WO2009/87224 A1) was stirred at 100° C. for 5 hours. The solvent was distilled away under reduced pressure, and a yellow solid of 1-(5-bromopyridin-3-yl)-3-(dimethylamino)prop-2-ene-1-one was thus obtained.

Workup

  1. distillationThe solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-8371d949cecf46f8ac72016070dd130c
Source dataset
uspto-grants-2014_07
Patent number
US08772320B2

Reaction notes

Loading…