Potassium Carbonate → 6-(5-Nitropyridin-2-yl)-2-oxa-6-azaspiro[3.3]heptane

HRID 1620093Notes

Reaction equation

C(=O)([O-])[O-].[K+].[K+].[CH2:7]1[C:10]2([CH2:13][NH:12][CH2:11]2)[CH2:9][O:8]1.CO.CN(C=O)C.Cl[C:22]1[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][N:23]=1>O>[N+:28]([C:25]1[CH:26]=[CH:27][C:22]([N:12]2[CH2:13][C:10]3([CH2:9][O:8][CH2:7]3)[CH2:11]2)=[N:23][CH:24]=1)([O-:30])=[O:29]

Participants

Conditions

Temperature: 80 °C

Procedure

Potassium carbonate (78 mg) and 2-oxa-6-azaspiro[3.3]heptane (30 mg) were added to a methanol/DMF (1 ml/2 ml) solution containing 2-chloro-5-nitropyridine (30 mg), followed by stirring at 80° C. for 3 hours. The reaction solution was adjusted to room temperature, and water was added, followed by extraction with ethyl acetate. The resultant was washed with saturated saline and dried over anhydrous sodium sulfate, the solvent was distilled away under reduced pressure, the obtained residue was purified by silica gel chromatography (n-hexane:ethyl acetate=1:1 to 1:4), and a white solid of 6-(5-nitropyridin-2-yl)-2-oxa-6-azaspiro[3.3]heptane (23 mg) was thus obtained.

Workup

customwas adjusted to room temperature
extractionfollowed by extraction with ethyl acetate
washThe resultant was washed with saturated saline
dry with materialdried over anhydrous sodium sulfate
distillationthe solvent was distilled away under reduced pressure
customthe obtained residue was purified by silica gel chromatography (n-hexane:ethyl acetate=1:1 to 1:4)

Sources & evidence

ORD record: ord-cea368ff20f14b70b8c65134cec8ff3e
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08772320B2

Reaction notes

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