Cyclopropanesulfonyl chloride → HCID 56603048, compound

HRID 1620313Notes

Reaction equation

HRID 1620313 reaction equation
[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH:10]=[C:11]([CH:15]=[CH:16][C:17]=2[O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:12]([NH2:14])=[O:13])=[CH:7][CH:6]=[CH:5][N:4]=1.[CH:25]1([S:28](Cl)(=[O:30])=[O:29])[CH2:27][CH2:26]1>>[CH:25]1([S:28]([NH:14][C:12](=[O:13])[C:11]2[CH:15]=[CH:16][C:17]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[C:9]([C:8]3[C:3]([O:2][CH3:1])=[N:4][CH:5]=[CH:6][CH:7]=3)[CH:10]=2)(=[O:30])=[O:29])[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 2760919Cyclopropanesulfonyl chlorideHCID 66666483HCID 66666483, compound

Product 1

HCID 56603048HCID 56603048, compoundYield 17%

Procedure

Prepared according to Example 5 with 3-(2-methoxypyridin-3-yl)-4-phenoxybenzamide (Preparation 19, 0.030 g, 0.09 mmol) and cyclopropylsulfonyl chloride (0.030 g, 0.21 mmol). The product was purified by preparative HPLC to afford the title compound as a white solid (6.5 mg).

Workup

  1. customPrepared
  2. customThe product was purified by preparative HPLC

Sources & evidence

ORD record
ord-a944cf37e8304f0c9a8047b954967528
Source dataset
uspto-grants-2014_07
Patent number
US08772343B2

Reaction notes

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