Sodium Iodide → 8-(Biphenyl-2-yloxy)-octan-1-ol

HRID 1620356Notes

Reaction equation

HRID 1620356 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[I-].[Na+].[OH-].[Na+].Cl[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][OH:27]>O>[C:3]1([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[O:1][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][OH:27]

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 7017(1,1'-Biphenyl)-2-olHCID 14798Sodium HydroxideHCID 900121-Octanol, 8-chloro-

Product 1

HCID 667327408-(Biphenyl-2-yloxy)-octan-1-ol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The compound was prepared using essentially the procedure of Preparatory Example 1 with 2-hydroxy biphenyl (40 g.), water (250 g.), sodium iodide (3.5 g.) and sodium hydroxide (37.6 g. of 50% in water). This mixture was heated to 100° C. with agitation and 8-chloro-1-octanol (77.4 g.) was added. The product was recovered essentially as in Preparatory Example 1.

Workup

  1. customThe compound was prepared
  2. additionwas added
  3. customThe product was recovered essentially as in Preparatory Example 1

Sources & evidence

ORD record
ord-bc003a526a2440bbad59bebea4b6d194
Source dataset
uspto-grants-2014_07
Patent number
US08772425B2

Reaction notes

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