Hydrochloric Acid → methyl (S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride

HRID 1620377Notes

Reaction equation

C(OC([NH:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.[ClH:21]>CO>[ClH:21].[ClH:21].[NH2:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12]

Participants

Conditions

Temperature: 40 °C

Procedure

A solution of 750 mg (2.6 mmol) of methyl(S)-3-tert-butoxycarbonylamino-2-piperidin-1-ylpropanoate in 6 ml of methanol and 6 ml of isopropanolic hydrochloric acid, having a concentration of 5-6N, is stirred at 40° C. for 18 h. After concentration under vacuum, the residue is taken up in ethyl acetate, filtered and dried under vacuum. 670 mg (98%) of methyl(S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride are obtained in the form of a white solid.

Workup

concentrationAfter concentration under vacuum
filtrationfiltered
customdried under vacuum

Sources & evidence

ORD record: ord-ffd2b19576874ea497829ff151111215
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08772478B2

Reaction notes

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