Hydrochloric Acid → HCID 67495199, compound

Participants

Reaction Steps

A solution of 2.9 g (11 mmol) of methyl(S)-3-tert-butoxycarbonylamino-2-pyrrolidin-1-ylpropanoate in 20 ml of isopropanolic hydrochloric acid having a concentration of 5-6N is stirred at 40° C. for 18 h. After evaporation under vacuum, the residue is taken up in 100 ml of diethyl ether, stirred at ambient temperature for 1 h, filtered and dried under vacuum. 2.3 g (88%) of methyl(S)-3-amino-2-pyrrolidin-1-ylpropanoate dihydrochloride are obtained in the form of a beige solid.

Provenance & Evidence