Hydrochloric Acid → HCID 67495199, compound

HRID 1620383Notes

Reaction equation

HRID 1620383 reaction equation
C(OC([NH:8][CH2:9][C@H:10]([N:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.[ClH:20]>>[ClH:20].[ClH:20].[NH2:8][CH2:9][C@H:10]([N:15]1[CH2:16][CH2:17][CH2:18][CH2:19]1)[C:11]([O:13][CH3:14])=[O:12]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67494855HCID 67494855, compound

Product 1

HCID 67495199HCID 67495199, compoundYield 88%

Procedure

A solution of 2.9 g (11 mmol) of methyl(S)-3-tert-butoxycarbonylamino-2-pyrrolidin-1-ylpropanoate in 20 ml of isopropanolic hydrochloric acid having a concentration of 5-6N is stirred at 40° C. for 18 h. After evaporation under vacuum, the residue is taken up in 100 ml of diethyl ether, stirred at ambient temperature for 1 h, filtered and dried under vacuum. 2.3 g (88%) of methyl(S)-3-amino-2-pyrrolidin-1-ylpropanoate dihydrochloride are obtained in the form of a beige solid.

Workup

  1. customAfter evaporation under vacuum
  2. filtrationfiltered
  3. customdried under vacuum

Sources & evidence

ORD record
ord-205ee70126044fbd9eeaf1baffbdbd20
Source dataset
uspto-grants-2014_07
Patent number
US08772478B2

Reaction notes

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