HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1620391Generated: November 3, 2026
Hydrochloric Acid → methyl (S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride
https://huagongshe.com/reaction/1620391
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | methyl (R)-3-tert-butoxycarbonylamino-2-piperidin-1-ylpropanoate | HCID 123832673 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | methyl (S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride | HCID 67494635 | 100% |
Reaction Steps
3.7 g (12.9 mmol) of methyl (R)-3-tert-butoxycarbonylamino-2-piperidin-1-ylpropanoate are placed in a mixture of 25 ml of methanol and 15 ml of hydrochloric acid in solution in isopropanol having a concentration of 5-6N. The reaction medium is stirred at 40° C. for 18 h and then concentrated under vacuum. 3.5 g (100%) of methyl(S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride are obtained in the form of a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08772478B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-c0719296f1224f63b2fa688d882cb9e2 |
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| Source note | uspto-grants-2014_07 |
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