Hydrochloric Acid → methyl (S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride

HRID 1620391Notes

Reaction equation

C(OC([NH:8][CH2:9][C@@H:10]([N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.[ClH:21]>CO.C(O)(C)C>[ClH:21].[ClH:21].[NH2:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12]

Participants

Conditions

Temperature: 40 °C

Procedure

3.7 g (12.9 mmol) of methyl (R)-3-tert-butoxycarbonylamino-2-piperidin-1-ylpropanoate are placed in a mixture of 25 ml of methanol and 15 ml of hydrochloric acid in solution in isopropanol having a concentration of 5-6N. The reaction medium is stirred at 40° C. for 18 h and then concentrated under vacuum. 3.5 g (100%) of methyl(S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride are obtained in the form of a beige solid.

Workup

concentrationconcentrated under vacuum

Sources & evidence

ORD record: ord-c0719296f1224f63b2fa688d882cb9e2
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08772478B2

Reaction notes

Loading…