(+-)-3-Quinuclidinol → Ethyl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

HRID 1620436Notes

Reaction equation

HRID 1620436 reaction equation
N12CCC(CC1)C(O)C2.[CH:10]1[CH:11]=[CH:12][C:13]([C@@H:16]2[N:25]([C:26]([O:28][C@@H:29]3C4CCN(CC4)[CH2:30]3)=[O:27])[CH2:24][CH2:23][C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]2=3)=[CH:14][CH:15]=1>>[C:13]1([C@H:16]2[C:17]3[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:23][CH2:24][N:25]2[C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH:12]=[CH:11][CH:10]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 15381(+-)-3-QuinuclidinolHCID 154059Solifenacin

Product 1

HCID 25178885Ethyl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Procedure

This solution was taken for condensation reaction with (RS)-3-quinuclidinol in the next stage to prepare Solifenacin and its diastereomer.

Sources & evidence

ORD record
ord-d59b003254474475b8c6d97a9f5ba6fb
Source dataset
uspto-grants-2014_07
Patent number
US08772491B2

Reaction notes

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