Hydrochloric Acid → HCID 178456917, compound

HRID 1620488Notes

Reaction equation

HRID 1620488 reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]1[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH2:20][C:21]#[CH:22])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:8][CH2:7]1.[ClH:33]>C(O)C>[ClH:33].[F:32][C:2]([F:1])([F:31])[C:3]1[CH:26]=[C:25]([C:27]([F:29])([F:30])[F:28])[CH:24]=[CH:23][C:4]=1[CH2:5][N:6]1[CH2:7][CH2:8][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH2:20][C:21]#[CH:22])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178456914HCID 178456914, compound

Product 1

HCID 178456917HCID 178456917, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of (5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one (141 mg) in ethanol (1 mL) was added 6N hydrochloric acid (0.1 mL). The reaction mixture was stirred at room temperature for 1 hr, the solvent was evaporated under reduced pressure, and the residue was recrystallized from 2-butanone/heptane to give the title compound (100 mg).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customthe residue was recrystallized from 2-butanone/heptane

Sources & evidence

ORD record
ord-65fc0f16384e4de5a9272ba258241e7e
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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