Ethoxyethylamine → HCID 178467931, compound

HRID 1620490Notes

Reaction equation

HRID 1620490 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][NH2:6])[CH3:2].S=[C:8]1[CH2:12][S:11][C:10](=[O:13])[NH:9]1>C(O)C>[CH2:1]([O:3][CH2:4][CH2:5][NH:6][C:8]1[CH2:12][S:11][C:10](=[O:13])[N:9]=1)[CH3:2]

Participants

4

Reactant 2

HCID 66970EthoxyethylamineHCID 15395954-Sulfanylidene-1,3-thiazolidin-2-one

Product 1

HCID 178467931HCID 178467931, compoundYield 85.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-ethoxyethanamine (4.07 g) in ethanol (100 mL) was added 4-thioxo-1,3-thiazolidin-2-one (4.05 g), and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (4.90 g).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

Sources & evidence

ORD record
ord-cc5f7d83498a4c6a9e0b61fcef548c39
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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