2-(2-Methoxyethoxy)ethanamine → HCID 178496228, compound

HRID 1620522Notes

Reaction equation

HRID 1620522 reaction equation
S=[C:2]1[CH2:6][S:5][C:4](=[O:7])[NH:3]1.[CH3:8][O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][NH2:15]>C(O)C>[CH3:8][O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][NH:15][C:2]1[CH2:6][S:5][C:4](=[O:7])[N:3]=1

Participants

4

Reactant 2

HCID 5205302-(2-Methoxyethoxy)ethanamineHCID 15395954-Sulfanylidene-1,3-thiazolidin-2-one

Product 1

HCID 178496228HCID 178496228, compoundYield 84.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4-thioxo-1,3-thiazolidin-2-one (2.24 g) in ethanol (20 mL) was added 2-(2-methoxyethoxy)ethanamine (2.5 g), and the mixture was stirred at room temperature for 5 hr. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate) to give the title compound (3.1 g).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (ethyl acetate)

Sources & evidence

ORD record
ord-5cf11b4d936848579ae1dbc183df1ea3
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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