HCID 86678720, compound → [2-(2-aminoethoxy)ethyl]diethylamine

HRID 1620532Notes

Reaction equation

HRID 1620532 reaction equation
[CH2:1]([N:3]([CH2:17][CH3:18])[CH2:4][CH2:5][O:6][CH2:7][CH2:8][NH:9]C(=O)OC(C)(C)C)[CH3:2]>Cl.C(OCC)(=O)C>[NH2:9][CH2:8][CH2:7][O:6][CH2:5][CH2:4][N:3]([CH2:1][CH3:2])[CH2:17][CH3:18]

Participants

3

Reactant 1

HCID 86678720HCID 86678720, compound

Product 1

HCID 15105206[2-(2-aminoethoxy)ethyl]diethylamineYield 96.1%

Reagents, catalysts & solvents 1

HCID 21866389Hydrogen chloride-ethyl acetateSolvent

Procedure

A mixed solution of tert-butyl {2-[2-(diethylamino)ethoxy]ethyl}carbamate (3.77 g) and 4M hydrogen chloride/ethyl acetate solution (40 mL) was stirred at room temperature for 3 hr, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate) to give the title compound (2.23 g).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate)

Sources & evidence

ORD record
ord-677aa69319024a308fd387f0c5064131
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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