Hydrogen chloride-ethyl acetate → HCID 178459303, compound

HRID 1620540Notes

Reaction equation

HRID 1620540 reaction equation
[OH:1][C:2]([CH3:26])([CH3:25])[CH2:3][NH:4][C:5]1=[N:6][C:7](=[O:24])[S:8]/[C:9]/1=[CH:10]\[CH:11]1[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]1.[ClH:27].C(OCC)(=O)C>>[ClH:27].[ClH:27].[OH:1][C:2]([CH3:26])([CH3:25])[CH2:3][NH:4][C:5]1=[N:6][C:7](=[O:24])[S:8]/[C:9]/1=[CH:10]\[CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178459309HCID 178459309, compound

Product 1

HCID 178459303HCID 178459303, compound

Procedure

A mixed solution of tert-butyl 4-[(Z)-{4-[(2-hydroxy-2-methylpropyl)amino]-2-oxo-1,3-thiazol-5(2H)-ylidene}methyl]piperidine-1-carboxylate (1.93 g) and 4M hydrogen chloride/ethyl acetate solution (20 mL) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure to give the title compound (1.70 g).

Workup

  1. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-bb348437253840e1af5c454285d4bd7f
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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