Acetonitrile, 2-(methylamino)- → HCID 67504117, compound

HRID 1620577Notes

Reaction equation

HRID 1620577 reaction equation
[CH3:1][NH:2][CH2:3][C:4]#[N:5].[C:6]([N:14]=[C:15]=[O:16])(=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C1COCC1>[NH:5]=[C:4]1[CH2:3][N:2]([CH3:1])[C:15](=[O:16])[N:14]1[C:6]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:13]

Participants

4

Reactant 2

HCID 36652Acetonitrile, 2-(methylamino)-HCID 78210Benzoyl isocyanate

Product 1

HCID 67504117HCID 67504117, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of N-methylaminoacetonitrile (6.19 g) in anhydrous THF (100 mL) was added benzoyl isocyanate (13.0 g) under ice-cooling. The reaction mixture was stirred at room temperature for 5 hr. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (18.6 g).

Workup

  1. temperaturecooling
  2. customThe solvent was evaporated under reduced pressure
  3. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

Sources & evidence

ORD record
ord-7852200085184b4da4c1869aef262694
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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