1-Propanol, 3-amino-2,2-dimethyl- → HCID 178450595, compound

HRID 1620583Notes

Reaction equation

HRID 1620583 reaction equation
[NH2:1][CH2:2][C:3]([CH3:7])([CH3:6])[CH2:4][OH:5].S=[C:9]1[CH2:13][S:12][C:11](=[O:14])[NH:10]1>C(O)C>[OH:5][CH2:4][C:3]([CH3:7])([CH3:6])[CH2:2][NH:1][C:9]1[CH2:13][S:12][C:11](=[O:14])[N:10]=1

Participants

4

Reactant 2

HCID 1173261-Propanol, 3-amino-2,2-dimethyl-HCID 15395954-Sulfanylidene-1,3-thiazolidin-2-one

Product 1

HCID 178450595HCID 178450595, compoundYield 58.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 3-amino-2,2-dimethylpropan-1-ol (4.05 g) in ethanol (100 mL) was added 4-thioxo-1,3-thiazolidin-2-one (5.07 g). The reaction mixture was stirred at room temperature overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate) to give the title compound (4.52 g).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (NH, ethyl acetate)

Sources & evidence

ORD record
ord-1e8ad6e4e16f458eb55aec780dd7dd9c
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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