HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Tert-butyl-dimethyl-silanyloxymethyl)-1-cycloheptyl-3,3-dimethyl-pyrrolidin-2-one → 1-Cycloheptyl-4-hydroxymethyl-3,3-dimethyl-pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Tert-butyl-dimethyl-silanyloxymethyl)-1-cycloheptyl-3,3-dimethyl-pyrrolidin-2-one | HCID 131727096 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Cycloheptyl-4-hydroxymethyl-3,3-dimethyl-pyrrolidin-2-one | HCID 66665288 | — |
Reaction Steps
Two drops of 12M HCl was added to a solution of Example 1D (75 mg, 0.21 mmoles) in methanol (1.25 mL) and stirred for one hour at room temperature. The solvent was evaporated in vacuo to provide the title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737137B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-272aeb37cfe24c39bb51f81365c79ccf |
| Source note | uspto-grants-2010_06 |