4-(Tert-butyl-dimethyl-silanyloxymethyl)-1-cycloheptyl-3,3-dimethyl-pyrrolidin-2-one → 1-Cycloheptyl-4-hydroxymethyl-3,3-dimethyl-pyrrolidin-2-one

HRID 16206Notes

Reaction equation

HRID 16206 reaction equation
C([SiH2][O:6][C:7](C)(C)[CH:8]1[CH2:12][N:11]([CH:13]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[C:10](=[O:20])[C:9]1([CH3:22])[CH3:21])(C)(C)C>Cl.CO>[CH:13]1([N:11]2[CH2:12][CH:8]([CH2:7][OH:6])[C:9]([CH3:21])([CH3:22])[C:10]2=[O:20])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1

Participants

4

Reactant 1

HCID 1317270964-(Tert-butyl-dimethyl-silanyloxymethyl)-1-cycloheptyl-3,3-dimethyl-pyrrolidin-2-one

Product 1

HCID 666652881-Cycloheptyl-4-hydroxymethyl-3,3-dimethyl-pyrrolidin-2-one

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 887MethanolSolvent

Procedure

Two drops of 12M HCl was added to a solution of Example 1D (75 mg, 0.21 mmoles) in methanol (1.25 mL) and stirred for one hour at room temperature. The solvent was evaporated in vacuo to provide the title compound as a colorless oil.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-272aeb37cfe24c39bb51f81365c79ccf
Source dataset
uspto-grants-2010_06
Patent number
US07737137B2

Reaction notes

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