HCID 178524562, compound → 2-Oxopiperidine-4-carboxylic acid

HRID 1620601Notes

Reaction equation

HRID 1620601 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][N:3]=1>CO.[OH-].[OH-].[Pd+2]>[O:1]=[C:2]1[CH2:7][CH:6]([C:8]([OH:10])=[O:9])[CH2:5][CH2:4][NH:3]1

Participants

4

Reactant 1

HCID 178524562HCID 178524562, compound

Product 1

HCID 552860802-Oxopiperidine-4-carboxylic acidYield 92.3%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

A solution of 2-hydroxypyridine-4-carboxylic acid (40.0 g) and 10% palladium hydroxide/carbon (8.0 g) in methanol (500 mL) was stirred at 30° C. for 24 hr under a hydrogen atmosphere (50 psi). The reaction mixture was filtered, the catalyst was removed, and the filtrate was concentrated under reduced pressure to give the title compound (38.0 g).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe catalyst was removed
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5125ef58daf14fa286ae2313d286450d
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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