4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178518112, compound

HRID 1620621Notes

Reaction equation

HRID 1620621 reaction equation
S=[C:2]1[CH2:6][S:5][C:4](=[O:7])[NH:3]1.[NH2:8][CH2:9][C:10]1([CH2:16][OH:17])[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>C(O)C>[OH:17][CH2:16][C:10]1([CH2:9][NH:8][C:2]2[CH2:6][S:5][C:4](=[O:7])[N:3]=2)[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 22379474[4-(Aminomethyl)oxan-4-yl]methanol

Product 1

HCID 178518112HCID 178518112, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 4-thioxo-1,3-thiazolidin-2-one (898 mg) in ethanol (15 mL) was added a solution (5 mL) of [4-(aminomethyl)tetrahydro-2H-pyran-4-yl]methanol (1.00 g) in ethanol, and the mixture was heated under reflux overnight. The reaction mixture was cooled to room temperature, the precipitate was collected by filtration, and the obtained powder was washed with ethyl acetate to give the title compound (1.44 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux overnight
  3. filtrationthe precipitate was collected by filtration
  4. washthe obtained powder was washed with ethyl acetate

Sources & evidence

ORD record
ord-c71d08864ab348c58adc3c6f894f5dd1
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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