HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen chloride-ethyl acetate → (3aR,6aS)-octahydrocyclopenta[c]pyrrol-5-ylmethanol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | rel-tert-Butyl (3aR,6aS)-5-(hydroxymethyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate | HCID 66669453 | — |
| Product | (3aR,6aS)-octahydrocyclopenta[c]pyrrol-5-ylmethanol hydrochloride | HCID 86678792 | — |
Reaction Steps
A solution of tert-butyl(3aR,6aS)-5-(hydroxymethyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (2.24 g) (WO 2006/14325 A2, 2006) in 4N hydrogen chloride/ethyl acetate (10 mL) was stirred at room temperature for 1 hr. The reaction mixture was concentrated to give the title compound (1.65 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772277B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-b8c310b1b81f48c5afb2a122eec8d63e |
| Source note | uspto-grants-2014_07 |