HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (R)-2-aminobut-3-yn-1-ol trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl (4R)-4-ethynyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate | HCID 11096274 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-2-aminobut-3-yn-1-ol trifluoroacetate | HCID 86678813 | — |
Reaction Steps
To a solution of (R)-tert-butyl 4-ethynyl-2,2-dimethyloxazolidine-3-carboxylate (680 mg) (Tetrahedron 1996, 52, 11215.) in methanol (20 mL) was added trifluoroacetic acid (0.23 mL). The reaction mixture was stirred at room temperature for 4 hr and concentrated under reduced pressure to give the title compound (623 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772277B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-5e0e3acfe6a741fa83d51040380aea2c |
| Source note | uspto-grants-2014_07 |