反应详情

To a solution of (R)-2-aminobut-3-yn-1-ol trifluoroacetate (601 mg) in ethanol (15 mL) were added 4-thioxo-1,3-thiazolidin-2-one (402 mg) and N-ethyl-N-(1-methylethyl)propan-2-amine (1.63 mL), and the mixture was heated under reflux overnight. The reaction mixture was concentrated under reduced pressure, the residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate), and the obtained powder was washed with ethyl acetate to give the title compound (112 mg).

1. temperaturethe mixture was heated
2. temperatureunder reflux overnight
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. customthe residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate)
5. washthe obtained powder was washed with ethyl acetate