HCID 86678817, compound → HCID 86678816, compound

HRID 1620650Notes

Reaction equation

HRID 1620650 reaction equation
C(OC(=O)[NH:10][C@H:11]([CH2:17][OH:18])[C:12]([N:14]([CH3:16])[CH3:15])=[O:13])C1C=CC=CC=1>CO.[C].[Pd]>[CH3:15][N:14]([CH3:16])[C:12](=[O:13])[C@@H:11]([CH2:17][OH:18])[NH2:10]

Participants

4

Reactant 1

HCID 86678817HCID 86678817, compound

Product 1

HCID 86678816HCID 86678816, compoundYield 104.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

A solution of (R)-benzyl[1-(dimethylamino)-3-hydroxy-1-oxopropan-2-yl]carbamate (1.30 g) and 10% palladium carbon (130 mg) in methanol (30 mL) was stirred at room temperature for 7 hr under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (673 mg).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d40d4c0d133e4d8699d273a2f6d7183e
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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