4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178521297, compound

HRID 1620662Notes

Reaction equation

HRID 1620662 reaction equation
[CH:1]1([NH:4][C:5](=[O:8])[CH2:6][NH2:7])[CH2:3][CH2:2]1.S=[C:10]1[CH2:14][S:13][C:12](=[O:15])[NH:11]1>C(O)C>[CH:1]1([NH:4][C:5](=[O:8])[CH2:6][NH:7][C:10]2[CH2:14][S:13][C:12](=[O:15])[N:11]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 49627272-amino-N-cyclopropylacetamide

Product 1

HCID 178521297HCID 178521297, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of N-cyclopropylglycinamide (1.22 g) (J. Med. Chem. 2005, 48, 7808-7820) in ethanol (12 mL) was added 4-thioxo-1,3-thiazolidin-2-one (1.42 g), and the mixture was stirred at room temperature for 5 hr. The precipitate was collected by filtration, and the solid was washed with ethanol to give the title compound (2.0 g).

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washthe solid was washed with ethanol

Sources & evidence

ORD record
ord-0b8204a8043e4a2d837411209ea78c16
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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