Cyclohexylamine → HCID 178517975, compound

HRID 1620677Notes

Reaction equation

HRID 1620677 reaction equation
S=[C:2]1[CH2:6][S:5][C:4](=[O:7])[NH:3]1.[CH:8]1([NH2:14])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1>C(O)C>[CH:8]1([NH:14][C:2]2[CH2:6][S:5][C:4](=[O:7])[N:3]=2)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 15395954-Sulfanylidene-1,3-thiazolidin-2-one

Product 1

HCID 178517975HCID 178517975, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4-thioxo-1,3-thiazolidin-2-one (1.00 g) in ethanol (30 mL) was added cyclohexylamine (0.88 mL), and the mixture was heated under reflux overnight. The reaction mixture was concentrated under reduced pressure, the residue was purified by silica gel column chromatography (ethyl acetate/hexane), and the obtained powder was washed with ethyl acetate to give the title compound (599 mg).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux overnight
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)
  5. washthe obtained powder was washed with ethyl acetate

Sources & evidence

ORD record
ord-62557213f626438cbb71da3c4d118dbf
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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