HCID 86678841, compound → HCID 45087500, compound

HRID 1620680Notes

Reaction equation

HRID 1620680 reaction equation
C(OC(=O)[NH:10][C@@H:11]([CH2:17][OH:18])[C:12]([N:14]([CH3:16])[CH3:15])=[O:13])C1C=CC=CC=1>CO.[C].[Pd]>[CH3:15][N:14]([CH3:16])[C:12](=[O:13])[C@H:11]([CH2:17][OH:18])[NH2:10]

Participants

4

Reactant 1

HCID 86678841HCID 86678841, compound

Product 1

HCID 45087500HCID 45087500, compoundYield 101.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

A solution of (S)-benzyl[1-(dimethylamino)-3-hydroxy-1-oxopropan-2-yl]carbamate (3.20 g) and 10% palladium carbon (320 mg) in methanol (30 mL) was stirred at room temperature for 5 hr under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (1.61 g).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-e7a15c9f9d9f46c3bafa3c3e8aa2fd5a
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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