HCID 71247139, compound → HCID 71352300, compound

HRID 1620691Notes

Reaction equation

HRID 1620691 reaction equation
C(OC(=O)[NH:10][C@@H:11]([CH2:17][C:18]([N:20]([CH3:22])[CH3:21])=[O:19])[C:12]([N:14]([CH3:16])[CH3:15])=[O:13])C1C=CC=CC=1>C(O)C.[C].[Pd]>[CH3:16][N:14]([CH3:15])[C:12](=[O:13])[C@H:11]([CH2:17][C:18]([N:20]([CH3:22])[CH3:21])=[O:19])[NH2:10]

Participants

4

Reactant 1

HCID 71247139HCID 71247139, compound

Product 1

HCID 71352300HCID 71352300, compoundYield 109.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of benzyl[(2S)-1,4-bis(dimethylamino)-1,4-dioxobutan-2-yl]carbamate (550 mg) in ethanol (5 mL) was added 10% palladium carbon (182 mg) at room temperature. The reaction mixture was stirred at room temperature for 5 hr under a hydrogen atmosphere. The solid was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (350 mg).

Workup

  1. customThe solid was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-54b081705d7a4a25b315a9c0e1973ee1
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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