HCID 178456890, compound → HCID 86678852, compound

HRID 1620692Notes

Reaction equation

HRID 1620692 reaction equation
[CH2:1]([NH:4][C:5]1[CH2:9][S:8][C:7](=[O:10])[N:6]=1)[C:2]#[CH:3]>CO>[N:4]1[CH:1]=[CH:2][CH2:3][N:6]2[C:7](=[O:10])[S:8][CH2:9][C:5]=12

Participants

3

Reactant 1

HCID 178456890HCID 178456890, compound

Product 1

HCID 86678852HCID 86678852, compoundYield 31.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one (120 mg) in methanol (2 mL) was stirred at 140° C. for 1 hr under microwave irradiation, and the solvent was evaporated. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (38 mg).

Workup

  1. customthe solvent was evaporated
  2. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

Sources & evidence

ORD record
ord-9a7df66fcf844223ba2186450621ddbc
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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