Triethylamine → HCID 178462003, compound

HRID 1620727Notes

Reaction equation

HRID 1620727 reaction equation
[CH3:1][N:2]([CH3:8])[C:3](=[O:7])[C@H:4]([CH3:6])[NH2:5].C(N(CC)CC)C.S=[C:17]1[CH2:21][S:20][C:19](=[O:22])[NH:18]1>C(O)C>[CH3:1][N:2]([CH3:8])[C:3](=[O:7])[C@H:4]([CH3:6])[NH:5][C:17]1[CH2:21][S:20][C:19](=[O:22])[N:18]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 12653780HCID 12653780, compound

Product 1

HCID 178462003HCID 178462003, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the crude product containing N,N-dimethylalaninamide obtained in C) and triethylamine (2 mL) in ethanol (20 mL) was added 4-thioxothiazolidin-2-one (1998 mg) at room temperature. The reaction mixture was stirred at room temperature overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (960 mg).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)

Sources & evidence

ORD record
ord-798cc931a40440d89e28e2f2f798ef50
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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