HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178518114, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Sulfanylidene-1,3-thiazolidin-2-one | HCID 1539595 | — |
| Reactant | 1-(1,3-Oxazol-2-yl)methanamine hydrochloride | HCID 46912060 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178518114 | HCID 178518114 | 48.7% |
Reaction Steps
To a solution of 1-(1,3-oxazol-2-yl)methanamine hydrochloride (500 mg) in ethanol (10 mL) were added triethylamine (0.99 mL) and 4-thioxothiazolidin-2-one (495 mg) at room temperature. The reaction mixture was stirred at room temperature overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate) to give the title compound (357 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772277B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-fb4ce50169624693b2ae0e676fd7ee32 |
| Source note | uspto-grants-2014_07 |