Triethylamine → HCID 178518114, compound

HRID 1620746Notes

Reaction equation

HRID 1620746 reaction equation
Cl.[O:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][NH2:8].C(N(CC)CC)C.S=[C:17]1[CH2:21][S:20][C:19](=[O:22])[NH:18]1>C(O)C>[O:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][NH:8][C:17]1[CH2:21][S:20][C:19](=[O:22])[N:18]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 469120601-(1,3-Oxazol-2-yl)methanamine hydrochloride

Product 1

HCID 178518114HCID 178518114, compoundYield 48.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1-(1,3-oxazol-2-yl)methanamine hydrochloride (500 mg) in ethanol (10 mL) were added triethylamine (0.99 mL) and 4-thioxothiazolidin-2-one (495 mg) at room temperature. The reaction mixture was stirred at room temperature overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate) to give the title compound (357 mg).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate)

Sources & evidence

ORD record
ord-fb4ce50169624693b2ae0e676fd7ee32
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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