Hydrogen chloride-ethyl acetate → 3-AMino-1-Methylpiperidin-2-one hydrochloride

Participants

Reaction Steps

To a solution of tert-butyl(1-methyl-2-oxopiperidin-3-yl)carbamate (960 mg) in ethyl acetate (10 mL) was added 4N hydrogen chloride/ethyl acetate (5 mL) at room temperature. The reaction mixture was stirred at room temperature overnight, and the solvent was evaporated under reduced pressure to give the title compound as a crude product.

Provenance & Evidence