Hydrogen chloride-ethyl acetate → 3-AMino-1-Methylpiperidin-2-one hydrochloride

HRID 1620752Notes

Reaction equation

HRID 1620752 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][CH2:11][N:10]([CH3:14])[C:9]1=[O:15])(C)(C)C.[ClH:17].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:17].[NH2:7][CH:8]1[CH2:13][CH2:12][CH2:11][N:10]([CH3:14])[C:9]1=[O:15]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57516591HCID 57516591, compound

Product 1

HCID 674161273-AMino-1-Methylpiperidin-2-one hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl(1-methyl-2-oxopiperidin-3-yl)carbamate (960 mg) in ethyl acetate (10 mL) was added 4N hydrogen chloride/ethyl acetate (5 mL) at room temperature. The reaction mixture was stirred at room temperature overnight, and the solvent was evaporated under reduced pressure to give the title compound as a crude product.

Workup

  1. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-aaf70acf95ec4427918690fe2023786f
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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