HCID 86678926, compound → HCID 86678927, compound

HRID 1620766Notes

Reaction equation

HRID 1620766 reaction equation
C(OC(=O)[NH:10][C@@H:11]([C:17]1([OH:20])[CH2:19][CH2:18]1)[C:12]([N:14]([CH3:16])[CH3:15])=[O:13])C1C=CC=CC=1>C(O)C.[C].[Pd]>[NH2:10][C@@H:11]([C:17]1([OH:20])[CH2:19][CH2:18]1)[C:12]([N:14]([CH3:16])[CH3:15])=[O:13]

Participants

4

Reactant 1

HCID 86678926HCID 86678926, compound

Product 1

HCID 86678927HCID 86678927, compoundYield 58.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of benzyl[(1S)-2-(dimethylamino)-1-(1-hydroxycyclopropyl)-2-oxoethyl]carbamate (190 mg) in ethanol (5 mL) was added 10% palladium carbon (69 mg) at room temperature. The reaction mixture was stirred at room temperature for 5 hr under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (60 mg).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a6aec1674a4342679378c216bd8f6d11
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

Loading…