HCID 25529914, compound → HCID 14963842, compound

HRID 1620770Notes

Reaction equation

HRID 1620770 reaction equation
C(OC(=O)[NH:10][C@@H:11]([CH:20]([CH3:22])[CH3:21])[C:12]([N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)=[O:13])C1C=CC=CC=1>C(O)C.[C].[Pd]>[NH2:10][C@@H:11]([CH:20]([CH3:22])[CH3:21])[C:12]([N:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1)=[O:13]

Participants

4

Reactant 1

HCID 25529914HCID 25529914, compound

Product 1

HCID 14963842HCID 14963842, compoundYield 79.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A solution of benzyl[(2S)-3-methyl-1-(morpholin-4-yl)-1-oxobutan-2-yl]carbamate (1.83 g) and 10% palladium carbon (0.608 g) in ethanol (30 mL) was stirred at room temperature overnight under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (850 mg).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3848dc638f7d40dc9d6880bb55e96593
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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