4-{[4-(Methylsulfinyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate → 3-{[4-(Methylsulfinyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

HRID 1620882Notes

Reaction equation

HRID 1620882 reaction equation
C(O[C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:21])[NH:12][C:13]2[S:14][CH:15]=[C:16]([S:18]([CH3:20])=[O:19])[N:17]=2)=[CH:7][CH:6]=1)(=O)C.[C:22]([O:25]C1C=CC=C(C(=O)NC2SC=C(SC)N=2)C=1)(=[O:24])[CH3:23]>>[C:22]([O:25][C:6]1[CH:5]=[CH:10][CH:9]=[C:8]([C:11](=[O:21])[NH:12][C:13]2[S:14][CH:15]=[C:16]([S:18]([CH3:20])=[O:19])[N:17]=2)[CH:7]=1)(=[O:24])[CH3:23]

Participants

3

Reactant 2

HCID 569693894-{[4-(Methylsulfinyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetateHCID 575719803-{[4-(Methylthio)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

Product 1

HCID 569693913-{[4-(Methylsulfinyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

Procedure

Using the above procedure for compound (3), 513 (0.61 g, 2.0 mmol) gives crude 5 as a white solid. The crude product is stirred in diethyl ether (30 mL) for 30 minutes, filtered and air dried to give 5 as a white solid.

Sources & evidence

ORD record
ord-03823bb81c1d4962baaddc978b0568cf
Source dataset
uspto-grants-2014_07
Patent number
US08772502B2

Reaction notes

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