Potassium hydroxy sulfite → 4-{[5-(Methylsulfinyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

HRID 1620886Notes

Reaction equation

HRID 1620886 reaction equation
[OH:1]OS([O-])=O.[K+].[C:7]([O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17](=[O:26])[NH:18][C:19]2[S:20][C:21]([S:24][CH3:25])=[CH:22][N:23]=2)=[CH:13][CH:12]=1)(=[O:9])[CH3:8]>C(Cl)(Cl)Cl>[C:7]([O:10][C:11]1[CH:12]=[CH:13][C:14]([C:17](=[O:26])[NH:18][C:19]2[S:20][C:21]([S:24]([CH3:25])=[O:1])=[CH:22][N:23]=2)=[CH:15][CH:16]=1)(=[O:9])[CH3:8]

Participants

4

Reactant 2

HCID 23707502Potassium hydroxy sulfiteHCID 575718204-{[5-(Methylsulfanyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

Product 1

HCID 569693934-{[5-(Methylsulfinyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Using the Oxone® procedure as described in section 1.5.1.7 for the synthesis of compound (I), 515 (0.841 g, 2.73 mmol) gives crude 7. The crude product is stirred with chloroform (50 mL) and the suspension is filtered. The pad is washed once with chloroform and air dried to give pure 7 (0.35 g) as a white solid.

Workup

  1. customgives crude 7
  2. filtrationthe suspension is filtered
  3. washThe pad is washed once with chloroform and air
  4. customdried

Sources & evidence

ORD record
ord-7e3ee9d730574924bdaf720001ab6ccb
Source dataset
uspto-grants-2014_07
Patent number
US08772502B2

Reaction notes

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