3,3,3-Trifluoropropanal → HCID 67298297, compound
Reaction equation
[CH3:1][O:2][C:3]([CH:5](P(OC)(OC)=O)[NH:6][C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8])=[O:4].C1CCN2C(=NCCC2)CC1.[F:34][C:35]([F:40])([F:39])[CH2:36][CH:37]=O>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:4])[C:5]([NH:6][C:7]([O:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:8])=[CH:37][CH2:36][C:35]([F:40])([F:39])[F:34]Participants
Conditions
- Temperature
- -30 °C
Procedure
N-(Benzyloxycarbonyl)-α-phosphonoglycine trimethyl ester and DBU were dissolved in dry methylene chloride (50 mL) and the reaction mixture was chilled to −30° C. 3,3,3-Trifluoropropanal (1 eq) was added dropwise to the chilled and stirred solution and the reaction was allowed to stir for an additional hour at −30° C., and then overnight at ambient temperature. Methylene chloride (ca. 100 mL) was added and the organic phase was washed with 1N HCl (ca. 100 mL), then saturated brine (ca. 100 mL). The organic phase was dried over MgSO4, filtered, and concentrated by rotary evaporation. This crude product was purified by silica gel chromatography with a gradient of 10-30% ethyl acetate in hexanes to yield 2-benzyloxycarbonylamino-5,5,5-trifluoro-pent-2-enoic acid methyl ester as a white, crystalline solid.
Workup
- temperaturechilled
- stirringto stir for an additional hour at −30° C.
- customovernight
- customat ambient temperature
- washthe organic phase was washed with 1N HCl (ca. 100 mL)
- dry with materialThe organic phase was dried over MgSO4
- filtrationfiltered
- concentrationconcentrated by rotary evaporation
- customThis crude product was purified by silica gel chromatography with a gradient of 10-30% ethyl acetate in hexanes
Sources & evidence
- ORD record
- ord-171e1f89cd8645b292735a41798b472a
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08772336B2
Reaction notes
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