huagongshe.com
HRID1620967

反应详情

EQUATION

反应方程式

HRID 1620967 的结构方程式

REACTANTS

反应物

4
结构：N#CCN
HCID10901

Aminoacetonitrile

C2H4N2

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

结构：CC(C)C[C@H](N[C@@H](c1ccc(Br)cc1)c1nccs1)C(=O)O
HCID67298316

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)C[C@H](N[C@@H](c1ccc(Br)cc1)c1nccs1)C(=O)NCC#N
HCID59715490

未命名化合物

PROCEDURE

实验过程

In the presence of HATU (1 eq.) and diisopropylethylamine (4 eq.), (2S)-2-{(S)-[(4-bromophenyl)-thiazol-2-yl-methyl]-amino}-4-methylpentanoic acid was coupled with aminoacetonitrile (2 eq., 1 eq. excess) to give (2S)-2-{(S)-[(4-bromophenyl)-thiazol-2-yl-methyl]-amino}-4-methylpentanoic acid cyanomethylamide as a cream solid.