HCID 3151737, compound → HCID 71279102, compound

HRID 1621090Notes

Reaction equation

HRID 1621090 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]([CH3:14])[N:8]([CH3:13])[C:9]=1[C:10]([OH:12])=O)=[O:4].[CH3:15][N:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[C:17]1[CH2:25][CH2:26][NH2:27]>>[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]([CH3:14])[N:8]([CH3:13])[C:9]=1[C:10](=[O:12])[NH:27][CH2:26][CH2:25][C:17]1[N:16]([CH3:15])[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=1)=[O:4]

Participants

3

Reactant 2

HCID 3151737HCID 3151737, compoundHCID 86677477HCID 86677477, compound

Product 1

HCID 71279102HCID 71279102, compound

Procedure

The product was obtained starting from 1,2-dimethyl-1H-imidazole-4,5-dicarboxylic acid 4-methyl ester (200 mg, 1.01 mmol) and 2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethanamine (195 mg, 1.11 mmol) according to the method described in example 7, step 5 after aqueous work-up and purification by flash chromatography (using silica gel amine phase and a MeOH/ethyl acetate gradient) as light red gum (98 mg, 276 μmol, 27.3%). MS: M=356.1 (M+H)+

Workup

  1. customThe product was obtained
  2. customafter aqueous work-up and purification by flash chromatography (

Sources & evidence

ORD record
ord-c067f49a1e7640abae00eb15a8b66155
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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