2-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochloride → 1-Methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-imidazole-4-carboxylic acid methyl ester

HRID 1621093Notes

Reaction equation

HRID 1621093 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][N:8]([CH3:13])[C:9]=1[C:10]([OH:12])=O)=[O:4].Cl.Cl.[CH3:16][N:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[C:18]1[CH2:26][CH2:27][NH2:28]>>[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][N:8]([CH3:13])[C:9]=1[C:10](=[O:12])[NH:28][CH2:27][CH2:26][C:18]1[N:17]([CH3:16])[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=1)=[O:4]

Participants

3

Reactant 2

HCID 450751602-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochlorideHCID 866774784-(Methoxycarbonyl)-1-methyl-1H-imidazole-5-carboxylic acid

Product 1

HCID 712792141-Methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-imidazole-4-carboxylic acid methyl ester

Procedure

The product was obtained starting from 1-methyl-1H-imidazole-4,5-dicarboxylic acid 4-methyl ester (200 mg, 1.09 mmol) and 2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethanamine dihydrochloride (296 mg, 1.19 mmol) according to the method described in example 8, step 3 as pink foam (156 mg, 457 μmol, 42.1%). MS: M=342.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-6130c401d93441b7a799b9b99bcc4979
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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