HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochloride → 1-Methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-imidazole-4-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochloride | HCID 45075160 | — |
| Reactant | 4-(Methoxycarbonyl)-1-methyl-1H-imidazole-5-carboxylic acid | HCID 86677478 | — |
| Product | 1-Methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-imidazole-4-carboxylic acid methyl ester | HCID 71279214 | — |
Reaction Steps
The product was obtained starting from 1-methyl-1H-imidazole-4,5-dicarboxylic acid 4-methyl ester (200 mg, 1.09 mmol) and 2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethanamine dihydrochloride (296 mg, 1.19 mmol) according to the method described in example 8, step 3 as pink foam (156 mg, 457 μmol, 42.1%). MS: M=342.1 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772510B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-6130c401d93441b7a799b9b99bcc4979 |
| Source note | uspto-grants-2014_07 |