2-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochloride → 2-Chloro-1-methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-imidazole-4-carboxylic acid methyl ester

HRID 1621095Notes

Reaction equation

HRID 1621095 reaction equation
Cl.Cl.[CH3:3][N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]=[C:5]1[CH2:13][CH2:14][NH2:15].[CH3:16][O:17][C:18]([C:20]1[N:21]=[C:22]([Cl:29])[N:23]([CH3:28])[C:24]=1[C:25](O)=[O:26])=[O:19]>>[CH3:16][O:17][C:18]([C:20]1[N:21]=[C:22]([Cl:29])[N:23]([CH3:28])[C:24]=1[C:25](=[O:26])[NH:15][CH2:14][CH2:13][C:5]1[N:4]([CH3:3])[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]=1)=[O:19]

Participants

3

Reactant 2

HCID 450751602-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochlorideHCID 712792542-chloro-1-methyl-1H-imidazole-4,5-dicarboxylic acid 4-methyl ester

Product 1

HCID 712792402-Chloro-1-methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-imidazole-4-carboxylic acid methyl ester

Procedure

The product was obtained starting from 2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethanamine dihydrochloride (125 mg, 504 μmol) and 2-chloro-1-methyl-1H-imidazole-4,5-dicarboxylic acid 4-methyl ester (172 mg, 787 μmol) according to the method described in example 8, step 3 as purple solid (77 mg, 205 μmol, 40.7%). MS: M=376.3 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-fa1ce4851fde4adc9d879fe44f7d4d41
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

Loading…